Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FAK-IN-4 (Compound 7d) has anticancer activities that can induce cell apoptosis. FAK-IN-4 is potential inhibitor of FAK [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | FAK-IN-4 (Compound 7d) has anticancer activities that can induce cell apoptosis. FAK-IN-4 is potential inhibitor of FAK [1]. |
In vitro | FAK-IN-4 (Compound 7d), at concentrations ranging from 0-200 µM over 72 hours, exhibits significant antiproliferative effects on triple-negative breast cancer (TNBC) cells [1]. At lower concentrations of 0-20 µM for 24 hours, it effectively inhibits cell invasion and migration in MDA-MB-231 cells [1]. Additionally, within the same concentration range but over a longer period of 72 hours, FAK-IN-4 induces a dose-dependent dephosphorylation of FAK at Y925 and promotes apoptosis in MDA-MB-231 cells [1]. It also disrupts the formation of focal adhesions (FAs) and stress fibers (SFs) in these cells [1]. Through cell proliferation assays involving various cell lines (MDA-MB-231, MDA-MB-157, MDA-MB-453, and MCF10A) and concentrations up to 200 µM for 72 hours, the growth of TNBC cells was inhibited with IC50 values ranging from 8.37 to 40.63 µM [1]. Cell invasion assays at concentrations of 5, 10, and 20 µM over 24 hours significantly reduced the invasion of MDA-MB-231 cells in a dose-dependent manner [1]. Western blot analysis confirmed the dose-dependent dephosphorylation of FAK at Y925 [1]. Apoptosis analysis, using the same cell line and concentration range over 72 hours, demonstrated an increase in apoptotic cells from 13.10% to 41.59%, also in a dose-dependent fashion [1]. |
分子量 | 334.41 |
分子式 | C20H22N4O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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FAK-IN-4 Inhibitor inhibitor inhibit