Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cells with an IC50 of 1.6 µM. At a dosage of 5 µM, it induces ferroptosis in ES-2 cells, which is mitigatable by the iron chelator deferoxamine (DFO), the antioxidant Trolox, or the ferroptosis inhibitor ferrostatin-1. Furthermore, it effectively reduces tumor volume in a 4T1 murine mammary carcinoma model with immunocompetent mice, but not in immunodeficient mice, when administered at 50 mg/kg bi-weekly.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 17,500 |
5 mg | 約 35 days | ¥ 77,000 |
10 mg | 約 35 days | ¥ 136,000 |
説明 | Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cells with an IC50 of 1.6 µM. At a dosage of 5 µM, it induces ferroptosis in ES-2 cells, which is mitigatable by the iron chelator deferoxamine (DFO), the antioxidant Trolox, or the ferroptosis inhibitor ferrostatin-1. Furthermore, it effectively reduces tumor volume in a 4T1 murine mammary carcinoma model with immunocompetent mice, but not in immunodeficient mice, when administered at 50 mg/kg bi-weekly. |
分子量 | 586.08 |
分子式 | C30H36ClN3O7 |
CAS No. | 2505218-38-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: Soluble
Methanol: Soluble
DMSO: Soluble
You can also refer to dose conversion for different animals. 詳細
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Ferroptocide 2505218-38-0 Inhibitor inhibitor inhibit