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Flanvotumab (IMC-20D7S) is a humanized monoclonal antibody directed against tyrosinase-related protein (TYRP1).Flanvotumab exhibits potent antitumor activity and acts through natural killer-mediated and antibody-dependent cell-mediated cytotoxicity (ADCC).
説明 | Flanvotumab (IMC-20D7S) is a humanized monoclonal antibody directed against tyrosinase-related protein (TYRP1).Flanvotumab exhibits potent antitumor activity and acts through natural killer-mediated and antibody-dependent cell-mediated cytotoxicity (ADCC). |
In vitro | Flanvotumab is developed based on TA99, a mouse IgG2a monoclonal antibody against TYRP1. TA99 is positioned in subcutaneous melanoma xenografts and inhibits the growth of syngeneic tumors in preclinical models[1].The antitumor effect of TA99 relies on the presence of intact antibodies, Fc receptors, and natural killer (NK) cells[1]. |
別名 | 20D7S, IMC 20D7S |
分子量 | N/A |
CAS No. | 1188277-05-5 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Flanvotumab 1188277-05-5 Proteases/Proteasome Tyrosinase 20D7S IMC 20D7S Inhibitor inhibitor inhibit