Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FTase-IN-1 (compound 17a) is a highly effective inhibitor of fanesyl transferase (FTase), exhibiting a remarkable IC50 value of 0.35 μM. This compound demonstrates significant cytotoxicity potential and exhibits powerful antitumor activity [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | FTase-IN-1 (compound 17a) is a highly effective inhibitor of fanesyl transferase (FTase), exhibiting a remarkable IC50 value of 0.35 μM. This compound demonstrates significant cytotoxicity potential and exhibits powerful antitumor activity [1]. |
In vitro | FTase-IN-1 (compound 17a) at a concentration of 10 μM over 48 hours, serves as an inhibitor of farnesyl transferase (FTase) and demonstrates significant inhibition of the NCI-60 cell proliferation in vitro [1]. Additionally, this compound effectively halts the growth of various cancer cell lines, achieving half-maximal growth inhibition (GI50) values ranging between 1.8 to 6.5 nM [1]. Through Cell Viability Assays [1], it has been shown to markedly inhibit cell growth across a diverse set of cancer types, including lung (NCI-H522), colon (COLO-205 and HT29), glioblastoma (SF-539), melanoma (MDA-MB-435), ovarian (OVCAR-3), and renal (A498) cancers, underlining its potent antitumor activities at the administered concentration and incubation period. |
分子量 | 384.45 |
分子式 | C23H16N2O2S |
CAS No. | 2490538-41-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
FTase-IN-1 2490538-41-3 Inhibitor inhibitor inhibit