Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1
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Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt), CAS N/A
パッケージサイズ |
在庫状況 |
単価(税別) |
500 μg |
約 35 days |
¥ 49,500 |
1 mg |
約 35 days |
¥ 87,500 |
5 mg |
約 35 days |
¥ 383,500 |
10 mg |
約 35 days |
¥ 672,500 |
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生物学的特性に関する説明
化学的特性
保存条件
& 溶解度情報
説明 |
Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1 |
保存条件
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度情報
DMSO: 5 mg/mL
DMF: 5 mg/mL
参考文献
1.
Liu, H.-X., Brumovsky, P., Schmidt, R., et al.Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptorsProc. Natl. Acad. Sci. USA98(17)9960-9964(2001)
2.
Lu, X., Lundstr?m, L., and Bartfai, T.Galanin (2-11) binds to GalR3 in transfected cell lines: Limitations for pharmacological definition of receptor subtypesNeuropeptides39(3)165-167(2005)
3.
Kuteeva, E., Wardi, T., Lundstr?m, L., et al.Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body levelNeuropsychopharmacology33(11)2573-2585(2008)
投与量変換
You can also refer to dose conversion for different animals.
詳細
In vivo投与量計算 (透明溶液)
ステップ1: 以下の情報を入力してください
溶媒の組成を入力してください
計算器
モル濃度計算機
希釈計算機
再構成計算
分子量計算機
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技術サポート
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keywords
Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
Galanin
Galanin (211) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
Galanin Amide
Galanin (2 11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
Inhibitor
inhibitor
inhibit