store at low temperature
store at -80°C
Garadacimab (CSL312) is a potent whole-human IgG4 monoclonal antibody targeting activation factor XII (FXIIa). Garadacimab can be used to study hereditary angioedema.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 72,000 |
5 mg | 在庫あり | ¥ 148,500 |
10 mg | 在庫あり | ¥ 226,500 |
25 mg | 在庫あり | ¥ 335,000 |
50 mg | 在庫あり | ¥ 452,500 |
100 mg | 在庫あり | ¥ 610,500 |
説明 | Garadacimab (CSL312) is a potent whole-human IgG4 monoclonal antibody targeting activation factor XII (FXIIa). Garadacimab can be used to study hereditary angioedema. |
ターゲット&IC50 | β-FXIIa:140 pM(Kd) |
In vitro | Garadacimab (CSL312) demonstrates high affinity to activated βFXIIa with a KD of 140 pM. In an activated partial thromboplastin time (aPTT) assay with human plasma, Garadacimab exhibits potency. Notably, it displays high selectivity over a panel of relevant human serine proteases, including FVIIa, FIXa, FXa, FXIa, kallikrein, tissue plasminogen activator, activated protein C, and urokinase plasminogen activator[2]. |
In vivo | In male and female cynomolgus monkeys, Garadacimab (0.5, 1, and 3 mg/kg i.v. and 6 and 20 mg/kg s.c. over 8 weeks) shows a dose-dependent increase in plasma concentrations[1]. Garadacimab exhibits an inhibitory effect on FXII-mediated kallikrein activity. Moreover, it induces a clear dose-dependent prolongation of activated partial thromboplastin time (aPTT) with no associated effect on the prothrombin time[1]. |
別名 | CSL312 |
分子量 | N/A |
CAS No. | 2162134-62-3 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Garadacimab 2162134-62-3 Metabolism Factor Xa CSL312 CSL-312 CSL 312 Inhibitor inhibitor inhibit