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Glembatumumab is a fully human IgG2 monoclonal antibody targeting the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma.Glembatumumab is a naked antibody to Glembatumumab vedotin and can be used to study antibody-activated molecule couplings (Glembatumumab vedotin ).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 60,500 |
5 mg | 在庫あり | ¥ 135,000 |
10 mg | 在庫あり | ¥ 217,500 |
25 mg | 在庫あり | ¥ 317,000 |
50 mg | 在庫あり | ¥ 434,000 |
100 mg | 在庫あり | ¥ 585,500 |
説明 | Glembatumumab is a fully human IgG2 monoclonal antibody targeting the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma.Glembatumumab is a naked antibody to Glembatumumab vedotin and can be used to study antibody-activated molecule couplings (Glembatumumab vedotin ). |
In vitro | Glembatumumab vedotin (CR011-vcMMAE) exhibits minimal growth inhibition at a concentration of 0.16 μg/mL in UACC62 melanoma cells without prior MEK inhibitor pretreatment for 72 hours. In contrast, the same dose of CR011-vcMMAE shows stronger growth inhibition in UACC62 cells pre-treated with a MEK inhibitor[1]. |
In vivo | Glembatumumab vedotin, administered via intravenous injection at a dose of 2.5 mg/kg three times within 7 days, inhibits tumor growth and demonstrates good tolerance in CB17SC scid?/? female xenograft mice[2]. |
分子量 | N/A |
CAS No. | 1020264-78-1 |
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You can also refer to dose conversion for different animals. 詳細
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Glembatumumab 1020264-78-1 Others Inhibitor inhibitor inhibit