Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM, demonstrating its ability to cross the blood-brain barrier. This compound also exhibits antioxidant properties and metal chelation capabilities. Additionally, it targets peripheral anion sites, potentially modulating β-amyloid and ameliorating neurodegeneration linked to Alzheimer's disease, highlighting its research potential for this condition [1].
説明 | hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM, demonstrating its ability to cross the blood-brain barrier. This compound also exhibits antioxidant properties and metal chelation capabilities. Additionally, it targets peripheral anion sites, potentially modulating β-amyloid and ameliorating neurodegeneration linked to Alzheimer's disease, highlighting its research potential for this condition [1]. |
ターゲット&IC50 | MAO-B:5.15 μM, AChE:0.44 μM, BChE:0.08 μM |
In vitro | hAChE-IN-3 (compound 5c) exhibits an IC50 of 36.28 μM in the SH-SY5Y cell line after 24 hours and an IC50 of 154.10 μM in the HepG2 cell line after 48 hours [1]. Additionally, hAChE-IN-3 demonstrates an IC50 of 2.58 μM against β-amyloid plaque aggregation with an inhibition rate of 59% at 10 μM [1]. |
分子量 | 541.98 |
分子式 | C30H24ClN3O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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hAChE-IN-3 Neuroscience Monoamine Oxidase Inhibitor inhibitor inhibit