Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hCAIX-IN-8 (compound 7i) is a highly potent and selective inhibitor of hCAIX, demonstrating potent inhibitory activity against CAIX with an IC50 value of 0.024 μM. It also exhibits inhibitory activity against CAII and CAVA with IC50 values of 1.99 μM and 1.10 μM, respectively. Furthermore, hCAIX-IN-8 exhibits anti-proliferative effects and low toxicity. It effectively reduces the occurrence of epithelial-to-mesenchymal transitions and promotes apoptosis. Additionally, hCAIX-IN-8 effectively inhibits cell migration and colonization potential [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | hCAIX-IN-8 (compound 7i) is a highly potent and selective inhibitor of hCAIX, demonstrating potent inhibitory activity against CAIX with an IC50 value of 0.024 μM. It also exhibits inhibitory activity against CAII and CAVA with IC50 values of 1.99 μM and 1.10 μM, respectively. Furthermore, hCAIX-IN-8 exhibits anti-proliferative effects and low toxicity. It effectively reduces the occurrence of epithelial-to-mesenchymal transitions and promotes apoptosis. Additionally, hCAIX-IN-8 effectively inhibits cell migration and colonization potential [1]. |
In vitro | hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC 50 是of 8.44, 11.22 μM for HT29, HepG2 cells, respectively [1]. hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1]. |
分子量 | 396.35 |
分子式 | C19H16N4O6 |
CAS No. | 2414633-40-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
hCAIX-IN-8 2414633-40-0 Inhibitor inhibitor inhibit