Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC-IN-32 is a highly effective HDAC inhibitor presenting IC50 values of 5.2, 11, and 28 nM for HDAC1, HDAC2, and HDAC6, respectively. This compound demonstrates notable anti-proliferative properties against tumor cells, as well as significant in vivo antitumor efficacy, which can elicit antitumor immunity [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | HDAC-IN-32 is a highly effective HDAC inhibitor presenting IC50 values of 5.2, 11, and 28 nM for HDAC1, HDAC2, and HDAC6, respectively. This compound demonstrates notable anti-proliferative properties against tumor cells, as well as significant in vivo antitumor efficacy, which can elicit antitumor immunity [1]. |
In vitro | HDAC-IN-32 (compound 9k) enhances Ac-HH3 and Ac-tubulin expression in tumor cells and triggers apoptosis through caspase-3 cleavage. It also decreases SSRP1 and SPT16 levels, causing chromatin damage. Moreover, HDAC-IN-32 outperforms SAHA in inhibiting tumor migration by reducing MMP-2 expression, crucial for tumor mobility [1]. |
分子量 | 353.41 |
分子式 | C20H23N3O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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HDAC-IN-32 Inhibitor inhibitor inhibit