Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC-IN-35 (Compound 14) is an effective and selective inhibitor of VEGFR-2 and HDAC, with IC50 values of 13.2 and 0.166 μM for VEGFR-2 and HDAC6, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | HDAC-IN-35 (Compound 14) is an effective and selective inhibitor of VEGFR-2 and HDAC, with IC50 values of 13.2 and 0.166 μM for VEGFR-2 and HDAC6, respectively. |
In vitro | HDAC-IN-35 (Compound 14), at concentrations ranging from 0 to 10 μM over a period of 48 hours, demonstrates anticancer effects across various cancer cell lines, including A549, PC-3, and SK-Hep-1, with IC50 values of 3.4, 1.9, and 3.2 μM respectively. Additionally, this compound exhibits potent anti-angiogenic activity, achieving over 50% growth inhibition (GI>50) at a concentration of 1.0 μM in human endothelial progenitor cells (EPCs) by targeting the VEGFR-2 pathway, and without evident systemic toxicity. Moderate inhibition of VEGFR-2 and the blocking of HDAC enzyme activity are key mechanisms through which HDAC-IN-35 delivers its anticancer properties. Furthermore, it concentration-dependently disrupts capillary-like tube formation in EPCs after 24 hours of treatment. In vitro assays support these findings; a Western Blot analysis revealed an increase in acetylated α-tubulin and histone H3, indicating a concentration-dependent reaction in cancer cells, along with a mild inhibition of VEGFR-2 phosphorylation in human EPCs, showcasing the compound's multifaceted anticancer and anti-angiogenic activities. |
分子量 | 399.75 |
分子式 | C17H13ClF3N3O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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HDAC-IN-35 Inhibitor inhibitor inhibit