Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-B-IN-1 for HDAC1 and MAO-B are 21.4 nM and 99.0 nM, respectively [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-B-IN-1 for HDAC1 and MAO-B are 21.4 nM and 99.0 nM, respectively [1]. |
In vitro | HDAC1/MAO-B-IN-1 (compound 1f) demonstrates inhibitory effects on hMAO-B, hMAO-A, and hHDAC1 with IC50 values of 99.0 nM, 9923.0 nM, and 21.4 nM, respectively [1]. Additionally, at a concentration of 50 μM over 24 hours, it exhibits neuroprotective effects and suppresses reactive oxygen species (ROS) production in PC12 cells, as confirmed by a Cell Viability Assay [1]. |
In vivo | Administered intragastrically (i.g.) at 20 mg/kg, HDAC1/MAO-B-IN-1 demonstrates favorable permeability across the blood-brain barrier (BBB) [1]. When administered intraperitoneally (i.p.) at 15 mg/kg for 15 consecutive days, it enhances the learning and memory functionalities in ICR mice, both male (6-8 weeks old) and female (20-25 g) models [1]. |
分子量 | 328.79 |
分子式 | C18H17ClN2O2 |
CAS No. | 2759855-37-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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HDAC1/MAO-B-IN-1 2759855-37-1 Inhibitor inhibitor inhibit