Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50= 0.025 μM). HDAC6-IN-5 inhibits Aβ 1-42 self-aggregation and AChE, with IC 50s of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50= 0.025 μM). HDAC6-IN-5 inhibits Aβ 1-42 self-aggregation and AChE, with IC 50s of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity. |
In vitro | HDAC6-IN-5 (compound 11b) effectively promotes the acetylation of histone H3 and α-tubulin in a dose-dependent manner, achieving half-maximal effects (EC 50 values) at concentrations of 0.58 μM for histone H3 and 8 μM for α-tubulin, respectively [1]. |
分子量 | 408.25 |
分子式 | C20H14BrN3O2 |
CAS No. | 2413603-15-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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HDAC6-IN-5 2413603-15-1 Inhibitor inhibitor inhibit