Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhibitor-47 is involved in the synthesis of derivatives of 1-(2-pyrimidinyl)piperazine, which have the potential to exhibit antianxiety, antidepressant, and antipsychotic effects [1] [2] [3].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhibitor-47 is involved in the synthesis of derivatives of 1-(2-pyrimidinyl)piperazine, which have the potential to exhibit antianxiety, antidepressant, and antipsychotic effects [1] [2] [3]. |
In vitro | APOBEC3G (A3G), a host cytidine deaminase, inhibits HIV-1 replication through its antiviral activity. Nonetheless, HIV-1 can circumvent this defense by exploiting the cellular ubiquitin/proteasome degradation pathway [1]. In response, HIV-1 inhibitor-47 specifically targets the APOBEC3G-apolipoprotein B mRNA editing enzyme catalytic subunit 3G (human), focusing on disrupting the HIV-1 Vif-APOBEC3G interaction [2]. |
分子量 | 242.28 |
分子式 | C12H14N6 |
CAS No. | 137448-39-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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HIV-1 inhibitor-47 137448-39-6 Inhibitor inhibitor inhibit