Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor with IC50s of 2.5 μΜ for hMAO-B and 3.84 μΜ for MB-COMT. hMAO-B/MB-COMT-IN-1 protects cells from oxidative damage that can be used in neurodegeneration disease research, for example, Parkinson’s Disease (PD) [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor with IC50s of 2.5 μΜ for hMAO-B and 3.84 μΜ for MB-COMT. hMAO-B/MB-COMT-IN-1 protects cells from oxidative damage that can be used in neurodegeneration disease research, for example, Parkinson’s Disease (PD) [1]. |
In vitro | hMAO-B/MB-COMT-IN-1 (compound 3, 50 μM, 24h) reduces resazurin reduction and induces lysosomal toxicity through reactive oxygen species (ROS) production in differentiated SH-SY5Y cells, as evidenced in studies [1]. At a lower concentration (10 μM, 30 min), it exhibits notable cytoprotective properties against t-BHP in these cells [1]. Furthermore, it is anticipated to traverse the blood-brain barrier (BBB) via passive diffusion, as suggested by results from the parallel artificial membrane permeability assay (PAMPA)-BBB kit [1]. |
分子量 | 273.33 |
分子式 | C16H19NO3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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hMAO-B/MB-COMT-IN-1 Inhibitor inhibitor inhibit