store at low temperature
store at -80°C
Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R. Ianalumab can inhibit the interaction between BAFF and BAFF-R and inhibit the protection of apoptosis mediated by BAFF. Ianalumab has antibody dependent cytotoxicity (ADCC) and works by activating effector cells mediated by the immune receptor tyrosine activation motif (ITAM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 51,000 |
5 mg | 在庫あり | ¥ 127,000 |
10 mg | 在庫あり | ¥ 183,000 |
25 mg | 在庫あり | ¥ 280,000 |
50 mg | 在庫あり | ¥ 379,000 |
100 mg | 在庫あり | ¥ 509,500 |
説明 | Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R. Ianalumab can inhibit the interaction between BAFF and BAFF-R and inhibit the protection of apoptosis mediated by BAFF. Ianalumab has antibody dependent cytotoxicity (ADCC) and works by activating effector cells mediated by the immune receptor tyrosine activation motif (ITAM). |
In vitro | Ianalumab (0.1 μg/mL; 72 h) exhibits potent antibody-dependent cell-mediated cytotoxicity (ADCC) against natural killer cells in chronic lymphocytic leukemia (CLL), promoting the production of cytokines[1]. |
In vivo |
Ianalumab (total dose: 100 mg/kg; once a week; for 2 weeks) increases the survival rate in a mouse model of chronic lymphocytic leukemia (CLL)[1]. Ianalumab (10 mg/kg; once a week; for 6 weeks), when modulated with Ibrutinib, demonstrates enhanced functionality of NK cells[1]. |
別名 | VAY-736 |
分子量 | N/A |
CAS No. | 1929549-92-7 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ianalumab 1929549-92-7 Others VAY736 VAY 736 VAY-736 Inhibitor inhibitor inhibit