store at low temperature
store at -80°C
Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2.
説明 | Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. |
ターゲット&IC50 | Hematologic cancer cells:0.05-65 ng/mL |
In vitro |
Idactamab exhibits inhibitory effects on various hematologic cancer cell lines, with an IC50 ranging from 0.05 to 65 ng/mL [2]. ASCT2 (SLC1A5) is a multi-channel, Na+-dependent neutral amino acid transporter that mediates the uptake of amino acids required for tumor growth and progression [2]. |
In vivo | Idactamab enhances the survival rates of three disseminated acute myeloid leukemia (AML) cell line models: TF1α (high expression of ASCT2), MOLM-13 (low expression of ASCT2), and M.V.411 (high expression of ASCT2). The corresponding minimum inhibitory concentrations are 0.05 mg/kg, 0.1 mg/kg, and 0.1 mg/kg, respectively [1]. |
別名 | INT-001 |
分子量 | N/A |
CAS No. | 2245205-37-0 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Idactamab 2245205-37-0 INT-001 Inhibitor inhibitor inhibit