Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis. Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 μg/ml, respectively) through cell cycle arrest and apoptosis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 22,500 |
5 mg | 約 35 days | ¥ 102,000 |
10 mg | 約 35 days | ¥ 179,000 |
25 mg | 約 35 days | ¥ 390,500 |
説明 | Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis. Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 μg/ml, respectively) through cell cycle arrest and apoptosis. |
分子量 | 602.8 |
分子式 | C38H50O6 |
CAS No. | 71117-97-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 25 mg/mL
Ethanol: 20 mg/mL
DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL
DMSO: 25 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Isogarcinol 71117-97-0 Inhibitor inhibitor inhibit