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Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6. Itolizumab slows T cell proliferation and inhibits the production of pro-inflammatory cytokines. Itolizumab can be used to study conditions as diverse as psoriasis, rheumatoid arthritis (RA) and COVID-19 disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 85,500 |
5 mg | 在庫あり | ¥ 223,000 |
10 mg | 在庫あり | ¥ 351,500 |
25 mg | 在庫あり | ¥ 523,500 |
50 mg | 在庫あり | ¥ 682,000 |
100 mg | 在庫あり | ¥ 959,500 |
説明 | Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6. Itolizumab slows T cell proliferation and inhibits the production of pro-inflammatory cytokines. Itolizumab can be used to study conditions as diverse as psoriasis, rheumatoid arthritis (RA) and COVID-19 disease. |
In vitro |
Inhibiting T cell proliferation, Itolizumab is effective at a concentration of 100 μg/mL[1]. In PBMCs, Itolizumab (0-100 μg/mL) inhibits Treg polarization and enhances the acquisition of the Th1 phenotype[1]. During overnight culture of PBMCs, Itolizumab at 40 μg/mL reduces CD26hiCD161+ CD8+ T cells[2]. In PBMCs stimulated in Th17 polarizing conditions, Itolizumab at 40 μg/mL for 3-12 days reduces the expression of IL-17 and IFN-γ[3]. |
In vivo | In a humanized xenograft mouse model of Graft Vs Host Disease (GVHD), Itolizumab demonstrates therapeutic efficacy when administered intraperitoneally at doses of 60 μg or 300 μg daily[4]. |
別名 | EQ-001 |
分子量 | N/A |
CAS No. | 1116433-11-4 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Itolizumab 1116433-11-4 Others EQ 001 EQ-001 EQ001 Inhibitor inhibitor inhibit