Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.
説明 | JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms. |
ターゲット&IC50 | JAK2:<250 nM (Ki), JAK3:<250 nM (Ki) |
In vitro | The Janus kinases (JAK), comprising JAK-1, JAK-2, JAK-3, and TYK-2, are essential tyrosine kinases in cytokine signaling, with their downstream targets including signal transducer and activator of transcription (STAT) proteins. The JAK/STAT pathway is crucial in mediating various aberrant immune responses, including allergies, asthma, autoimmune diseases, and both solid and hematologic malignancies[1]. |
分子量 | 345.79 |
分子式 | C20H12ClN3O |
CAS No. | 1036241-36-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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JAK-2/3-IN-1 1036241-36-7 JAK2/3IN1 JAK 2/3 IN 1 Inhibitor inhibitor inhibit