Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Laquinimod (ABR-215062) sodium is a carboxamide derivative administered orally that serves as a powerful immunomodulator, designed to prevent inflammation and neurodegeneration within the central nervous system. This compound effectively diminishes the activation of astrocytic NF-κB, offering protection against Cuprizone-induced demyelination. It shows promise for the treatment of both relapsing-remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS), in addition to its potential applications in the study of neurodegenerative diseases [1] [2] [3] [4].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 491,500 |
50 mg | 約6-8 週間 | ¥ 639,500 |
100 mg | 約6-8 週間 | ¥ 808,000 |
説明 | Laquinimod (ABR-215062) sodium is a carboxamide derivative administered orally that serves as a powerful immunomodulator, designed to prevent inflammation and neurodegeneration within the central nervous system. This compound effectively diminishes the activation of astrocytic NF-κB, offering protection against Cuprizone-induced demyelination. It shows promise for the treatment of both relapsing-remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS), in addition to its potential applications in the study of neurodegenerative diseases [1] [2] [3] [4]. |
In vitro | Laquinimod sodium effectively counters Experimental Autoimmune Encephalomyelitis (EAE) and suppresses deleterious T cell immune responses, primarily through direct action on myeloid Antigen-Presenting Cells (APC). It modifies myeloid APC subsets, curbing the polarization of Th1 and Th17 in myelin-specific T cells, and induces type II (M2) monocytes which reverse established EAE [1]. Additionally, Laquinimod modulates both the phenotype of B cells in healthy donors and the expression of regulatory markers in B cells of patients with Relapsing-Remitting Multiple Sclerosis (RRMS), alongside reducing IFNγ cytokine levels in CD4+ T cells [2]. |
In vivo | Laquinimod sodium treatment suppresses the ability of donor myelin-specific T cells to transfer Experimental Autoimmune Encephalomyelitis (EAE) to naive recipient mice. It also modifies myeloid antigen-presenting cell (APC) subpopulations in vivo, characterized by reduced numbers of CD11c+ CD11b+ CD4+ dendritic cells (DC) and increased levels of CD11b hi Gr1 hi monocytes [1]. |
分子量 | 378.79 |
分子式 | C19H16ClN2NaO3 |
CAS No. | 248282-07-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Laquinimod sodium 248282-07-7 Inhibitor inhibitor inhibit