Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 45,500 |
5 mg | 約 35 days | ¥ 204,500 |
10 mg | 約 35 days | ¥ 363,000 |
説明 | LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1]. |
In vivo | Pharmacokinetic results in mice indicate that compound LB244, administered at 10 mg/kg orally (po) and 5 mg/kg intraperitoneally (ip), exhibits limited oral bioavailability (C max = 0.04 μM) and a short half-life (T 1/2 = 2.8 h). Its in vivo clearance rate is 2854.3 mL/min/kg [1]. |
分子量 | 537.57 |
分子式 | C30H27N5O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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LB244 Immunology/Inflammation STING Inhibitor inhibitor inhibit