Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.
説明 | Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice. |
分子量 | 529.72 |
分子式 | C23H39N5O5S2 |
CAS No. | 59926-78-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform: Soluble
Methanol: Soluble
DMSO: Soluble
Ethanol: Soluble
You can also refer to dose conversion for different animals. 詳細
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Malformin C 59926-78-2 Inhibitor inhibitor inhibit