Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs the activities of MAO A, disrupts HSP90 binding, and downregulates both HER2 and phospho-Akt expressions, thereby inhibiting GBM growth. Additionally, it diminishes PD-L1 expression, thereby thwarting T cell activation and potential tumor immune evasion. MAO A/HSP90-IN-1 (4-b) is valuable for research into brain tumor-related diseases [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 349,000 |
50 mg | 約8-10 週間 | ¥ 454,500 |
100 mg | 約8-10 週間 | ¥ 574,000 |
説明 | MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs the activities of MAO A, disrupts HSP90 binding, and downregulates both HER2 and phospho-Akt expressions, thereby inhibiting GBM growth. Additionally, it diminishes PD-L1 expression, thereby thwarting T cell activation and potential tumor immune evasion. MAO A/HSP90-IN-1 (4-b) is valuable for research into brain tumor-related diseases [1]. |
ターゲット&IC50 | HSP90:0.019 μM, MAO-A:1.77 μM |
In vitro | MAO A/HSP90-IN-1 (4-b) at concentrations ranging from 0.1 μM to 3 μM over 24 hours inhibits the proliferation of GBM cells by suppressing MAO A and HSP90 [1]. The compound demonstrated an IC50 of 0.73 μM in GL26 cells, 1.68 μM in another GL26 trial, and 0.84 μM in U251R cells [1]. Additionally, MAO A/HSP90-IN-1 at 0μM, 0.35μM, 0.7μM, and 1.4μM reduced the expression of PD-L1 induced by IFN-γ in murine glioma GL26 cells after 24 hours [1]. |
In vivo | MAO A/HSP90-IN-1 (4-b) (25 mg/kg, intraperitoneal injection, daily) suppresses tumor growth in a murine GBM model [1]. |
分子量 | 444.95 |
分子式 | C24H29ClN2O4 |
CAS No. | 2927489-95-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MAO A/HSP90-IN-1 2927489-95-8 Neuroscience Monoamine Oxidase Inhibitor inhibitor inhibit