Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD06519, a novel camptothecin-based topoisomerase 1 inhibitor, through a maleimide-anchor and a cleavable glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) linker. ZW251 exhibits strong affinity for GPC3 in both human and cynomolgus monkey cells. It is characterized by rapid internalization in GPC3-positive Hepatocellular Carcinoma (HCC) cell lines and has the ability to induce bystander-mediated killing of GPC3-negative cancer cells [1].
説明 | MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD06519, a novel camptothecin-based topoisomerase 1 inhibitor, through a maleimide-anchor and a cleavable glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) linker. ZW251 exhibits strong affinity for GPC3 in both human and cynomolgus monkey cells. It is characterized by rapid internalization in GPC3-positive Hepatocellular Carcinoma (HCC) cell lines and has the ability to induce bystander-mediated killing of GPC3-negative cancer cells [1]. |
分子量 | 1038.04 |
分子式 | C51H56FN9O14 |
CAS No. | 2873460-70-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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MC-GGFG-AM-(10Me-11F-Camptothecin) 2873460-70-7 Inhibitor inhibitor inhibit