store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be used to study idiopathic pulmonary hypertension.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 27,500 | |||
10 mg | 在庫あり | ¥ 34,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 68,500 | |||
100 mg | 在庫あり | ¥ 104,500 |
説明 | MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be used to study idiopathic pulmonary hypertension. |
In vitro | In a concentration-dependent manner, MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration by blocking the migration inhibitory factor (MIF) pathway[1].By inhibiting the TGFβ1/Smad2/3 pathway, MIF098 reduces collagen synthesis and pulmonary artery fibrosis [1]. |
In vivo | Administered through intraperitoneal injection at a dose of 40 mg/kg once a day for 4 weeks, MIF098 attenuates the progression of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice [1]. |
分子量 | 255.27 |
分子式 | C15H13NO3 |
CAS No. | 1208448-95-6 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (313.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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MIF098 1208448-95-6 Others Inhibitor inhibitor inhibit