keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MTK458 (EP-0035985) is a brain-permeable and orally active PINK1 activator.MTK458 selectively activates PINK1 by stimulating dimerization and stabilization of the PINK1/TOM complexMTK458 drives the clearance of alpha-synaptic nucleoprotein pathology, and can be used to study Parkinson;s disease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 21,500 | |||
5 mg | 在庫あり | ¥ 52,500 | |||
10 mg | 在庫あり | ¥ 83,500 | |||
25 mg | 在庫あり | ¥ 171,000 | |||
50 mg | 在庫あり | ¥ 271,000 | |||
100 mg | 在庫あり | ¥ 372,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 58,000 |
説明 | MTK458 (EP-0035985) is a brain-permeable and orally active PINK1 activator.MTK458 selectively activates PINK1 by stimulating dimerization and stabilization of the PINK1/TOM complexMTK458 drives the clearance of alpha-synaptic nucleoprotein pathology, and can be used to study Parkinson;s disease. |
In vitro | MTK458 (25 µM) can bind to PINK1 and stabilize the active heterocomplex, thereby enhancing mitochondrial autophagy. MTK458 (0-13 µM, 10 days) mediates the clearance of α-synuclein pathology in vitro in the PFF seeding model and reduces pUb[1]. |
In vivo | In the striatum of mice injected with α-synuclein preformed fibrils (PFFs), MTK458 (50 mg/kg; oral gavage, once daily, for 6 months) rescued the activity deficit in freely moving PFF mice. It also reduced the levels of inflammatory markers (TREM2, IL-6, and CXCL1)[1]. |
別名 | EP-0035985 |
分子量 | 332.32 |
分子式 | C17H15F3N4 |
CAS No. | 2499962-58-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (240.73 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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MTK458 2499962-58-0 PI3K/Akt/mTOR signaling PTEN EP-0035985 Inhibitor inhibitor inhibit