Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective inhibitor of monoamine oxidase B (MAO-B) (IC50 = 1.33 nM) which can across the blood-brain barrier (BBB). Monoamine Oxidase B inhibitor 2 shows antioxidant and anti-neuroinflammatory activities which can be used in the study of Parkinson’s disease [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective inhibitor of monoamine oxidase B (MAO-B) (IC50 = 1.33 nM) which can across the blood-brain barrier (BBB). Monoamine Oxidase B inhibitor 2 shows antioxidant and anti-neuroinflammatory activities which can be used in the study of Parkinson’s disease [1]. |
In vitro | In cellular assays, Monoamine Oxidase B Inhibitor 2 (compound 8f; concentration range: 0.5-10.0 μM) markedly reduced the levels of NO and TNF-α in LPS-induced BV-2 cells [1]. |
In vivo | In an in vivo acute and subacute MPTP-induced mouse model of Parkinson’s disease, Monoamine Oxidase B inhibitor 2 (compound 8f; 6.3-39.5 mg/kg; orally administered) significantly ameliorated most behavioral disorders, restored dopamine levels, and reduced MDA content in the striatum of mice [1]. |
分子量 | 314.35 |
分子式 | C19H19FO3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Monoamine Oxidase B inhibitor 2 Inhibitor inhibitor inhibit