Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 24,000 | |||
10 mg | 在庫あり | ¥ 39,500 | |||
25 mg | 在庫あり | ¥ 85,500 | |||
50 mg | 在庫あり | ¥ 137,000 | |||
100 mg | 在庫あり | ¥ 202,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 27,000 |
説明 | MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation. |
ターゲット&IC50 | PRDM9:80 nM |
In vitro | After 24 hours of treatment, MRK-740 (3 μM) does not affect the growth of HEK293T cells at IC90, but some toxicity is observed at 10 μM. MRK-740 serves as an equivalent inhibitor of H3K4 methylation in MCF7 cells. In cells, MRK-740 selectively and directly inhibits H3K4 methylation at endogenous PRDM9 target sites[1]. |
分子量 | 464.56 |
分子式 | C25H32N6O3 |
CAS No. | 2387510-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (64.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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MRK-740 2387510-80-5 Chromatin/Epigenetic Histone Methyltransferase Inhibitor inhibitor inhibit