Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degradation of mutant EGFRs via both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways, and robustly suppresses the proliferation of NSCLC cells, indicating its potential utility in anticancer research [1].
説明 | MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degradation of mutant EGFRs via both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways, and robustly suppresses the proliferation of NSCLC cells, indicating its potential utility in anticancer research [1]. |
ターゲット&IC50 | EGFR (WT):17 nM (Kd), EGFR (L858R):10 nM (Kd) |
分子量 | 1151.82 |
分子式 | C60H76ClFN10O8S |
CAS No. | 2772612-96-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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MS9449 2772612-96-9 PROTAC PROTACs Inhibitor inhibitor inhibit