Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tethered to a small molecule that recruits and activates RNase L1. This interaction promotes the degradation of MYC mRNA, subsequently reducing MYC protein levels and inducing apoptosis, thereby presenting potential applications in anticancer research [1].
説明 | MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tethered to a small molecule that recruits and activates RNase L1. This interaction promotes the degradation of MYC mRNA, subsequently reducing MYC protein levels and inducing apoptosis, thereby presenting potential applications in anticancer research [1]. |
In vitro | MYC-RIBOTAC (0-10 μM; 48 hours) reduces the abundance of MYC mRNA and protein levels in HeLa cells in a dose-dependent and RNase L-dependent manner [1]. Additionally, MYC-RIBOTAC (0-10 μM; 48 hours) exhibits antiproliferative and apoptosis-inducing effects in both HeLa and Namalwa cells [1]. |
分子量 | 1067.17 |
分子式 | C55H58N10O11S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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MYC-RIBOTAC Cell Cycle/Checkpoint c-Myc Inhibitor inhibitor inhibit