N-hexadecanoyl-L-Homoserine lactone

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.[3] AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.[4] C16-HSL is one of a number of lipophilic, long acyl side-chain bearing AHLs, including its monounsaturated analog C16:1-(L)-HSL, produced by the LuxI AHL synthase homolog SinI involved in quorum-sensing signaling in S. meliloti, a nitrogen-fixing bacterial symbiont of certain legumes.[5],[6] C16-HSL is the most abundant AHL produced by the proteobacterium R. capsulatus and activates genetic exchange between R. capsulatus cells.[7] N-Hexadecanoyl-L-homoserine lactone and other hydrophobic AHLs tend to localize in relatively lipophilic cellular environments of bacteria and cannot diffuse freely through the cell membrane. The long-chain N-acylhomoserine lactones may be exported from cells by efflux pumps or may be transported between communicating cells by way of extracellular outer membrane vesicles.[8],[9]

N-hexadecanoyl-L-Homoserine lactone, CAS 87206-01-7

パッケージサイズ	在庫状況	単価(税別)
5 mg	約 35 days	￥ 22,000
10 mg	約 35 days	￥ 41,000
50 mg	約 35 days	￥ 167,500

ご確認事項

1. １研究室・グループあたり最大5製品までお申し込みいただけます。 同一製品は1回のみとなります。

2. １回につき最大2製品までのお申し込みが可能です。

3. ２回目以降をご希望の際は、前回ご提供のサンプルの実験結果をオンラインでご提供いただく必要がございます。

4. 2023 年 1 月 20 日より前にサンプルをお申し込みいただいたお客様は、2023 年の無料申請枠にはカウントされませんが、以前の実験結果をご提供いただく必要があります。

a. 初回申し込み

b. 2回目以降のお申込み

以上の条件に同意を得た上で、無償サンプルを申し込みます。

バルクのお問い合わせ

Get quote

正規代理店一覧

送信

キャンセル

You can also refer to dose conversion for different animals. 詳細

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

N-hexadecanoyl-L-Homoserine lactone 87206-01-7 C16-HSL N hexadecanoyl L Homoserine lactone NhexadecanoylLHomoserine lactone N-palmitoyl-L-Homoserine Inhibitor inhibitor inhibit