Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compound exhibits a remarkable selectivity of more than 800-fold towards recombinant GluN2C and GluN2D when compared to GluN2A and GluN2B. Furthermore, NAB-14 possesses the ability to penetrate the blood-brain-barrier effectively [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compound exhibits a remarkable selectivity of more than 800-fold towards recombinant GluN2C and GluN2D when compared to GluN2A and GluN2B. Furthermore, NAB-14 possesses the ability to penetrate the blood-brain-barrier effectively [1]. |
In vitro | NAB-14 (compound 14) demonstrates inhibitory effects, with IC50 values of 15 μM and 5.1 μM for GluN1/2AC1/2CC2 receptors, respectively [1]. At a concentration of 20 μM for 24 hours, it selectively inhibits GluN2D-containing receptors in brain slices, while not affecting GluN2A- or GluN2B-containing NMDARs in cultured cortical neurons [1]. Furthermore, a 10 μM concentration of NAB-14 decreases the peak amplitude of evoked excitatory postsynaptic currents (EPSCs) to 55 ± 3.0% and significantly lowers the τW of EPSC deactivation [1]. Additionally, at the same concentration, it reduces the peak amplitude and charge transfer of interneuron EPSCs to 59 ± 9.9% and 63 ± 9.7%, respectively, and decreases τW for interneuron EPSCs from 150 ± 12 ms to 101 ± 14 ms [1]. |
In vivo | NAB-14 (20 mg/kg; p.o.) demonstrates significant systemic exposure, achieving peak brain concentrations of 3.2 nM and 3.8 nM in mice and rats, respectively. This was observed in animal models using both mice and rats, with a dosage of 20 mg/kg administered orally. |
分子量 | 351.4 |
分子式 | C20H21N3O3 |
CAS No. | 1237541-73-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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NAB-14 1237541-73-9 Others Inhibitor inhibitor inhibit