keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases.
説明 | Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases. |
ターゲット&IC50 | ETA:0.679 nM (Ki), ETB:569 nM (Ki) |
In vitro | Nebentan potassium also inhibited endothelin-1-induced vasoconstriction in isolated rat aorta with a pA(2) value of 7.6[1]. |
In vivo | In medullary rats, the DR(2) values of Nebentan potassium are 0.53 mg/kg and 0.77 mg/kg, respectively. When administered orally at 1 mg/kg, Nebentan potassium maintains its antagonistic effects in conscious rats for over 6.5 hours[1]. |
別名 | YM598 |
分子量 | 529.61 |
分子式 | C24H20KN5O5S |
CAS No. | 342005-82-7 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (188.82 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Nebentan potassium 342005-82-7 GPCR/G Protein Endothelin Receptor YM598 Inhibitor inhibitor inhibit