Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nelonicline citrate (ABT-126) is an orally active and selective α7 nicotinic receptor agonist, demonstrating a high affinity for α7 nAChRs in the human brain (Ki = 12.3 nM). This compound is utilized in the research of schizophrenia and Alzheimer's disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 383,500 |
50 mg | 約6-8 週間 | ¥ 500,500 |
100 mg | 約6-8 週間 | ¥ 643,000 |
説明 | Nelonicline citrate (ABT-126) is an orally active and selective α7 nicotinic receptor agonist, demonstrating a high affinity for α7 nAChRs in the human brain (Ki = 12.3 nM). This compound is utilized in the research of schizophrenia and Alzheimer's disease. |
In vitro | Nelonicline citrate acts as an agonist with strong affinity towards α7 nicotinic acetylcholine receptors (nAChRs) in the human brain, demonstrated by a binding affinity (K i ) of 12.3 nM. It effectively activates currents in Xenopus oocytes expressing recombinant human α7 nAChRs, with an EC 50 value of 2 μM and an intrinsic activity 74% that of acetylcholine. Although it also binds to α3β4* nAChRs in human IMR-32 neuroblastoma cells with a K i value of 60 nM, its efficacy is significantly lower, showing just 12% efficacy at a concentration of 100,000 nM in calcium flux assays. Additionally, nelonicline citrate acts as a 5-HT3 receptor antagonist, though its affinity for this receptor is more than 10-fold lower than for α7 nAChRs, with a K i of 140 nM, aligning with the behavior of some other α7 nAChR agonists. |
別名 | ABT-126 citrate |
分子量 | 505.54 |
分子式 | C23H27N3O8S |
CAS No. | 1026136-84-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Nelonicline citrate 1026136-84-4 ABT-126 Citrate ABT 126 Citrate Nelonicline Citrate ABT126 Citrate ABT-126 citrate Inhibitor inhibitor inhibit