Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.NP10679 inhibits histamine H1, hERG channels, and CYP enzymes, and may be useful in the study of epilepsy and ischemic stroke.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 67,500 |
5 mg | 在庫あり | ¥ 166,000 |
10 mg | 在庫あり | ¥ 226,500 |
25 mg | 在庫あり | ¥ 349,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
説明 | NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.NP10679 inhibits histamine H1, hERG channels, and CYP enzymes, and may be useful in the study of epilepsy and ischemic stroke. |
ターゲット&IC50 | α1A-adrenoceptor:0.154 μM, α2C-adrenoceptor:3.09 μM (Ki), α1D-adrenoceptor:0.495 μM (Ki), H1 Receptor:0.073 μM, α1A-adrenoceptor:0.603 μM (Ki), α1B-adrenoceptor:1.92 μM (Ki), H1 Receptor:0.04 μM (Ki) |
In vitro | NP10679 is an NMDA receptor inhibitor containing GluN2B that is more effective than physiological pH. It exhibits inhibitory effects on 5-HT2A, α1A adrenergic receptor, H1 histamine receptor, and hERG channels[2]. |
In vivo | In the Male C57BL/6 middle cerebral artery occlusion (MCAo) model of transient ischemia mice, NP10679 (2, 5, and 10 mg/kg; intraperitoneal injection; administered 15 minutes prior to transient ischemia) dose-dependently reduces infarct volumes, with an ED50 of 1 mg/kg[2]. |
分子量 | 449.47 |
分子式 | C23H26F3N3O3 |
CAS No. | 2914889-88-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (177.99 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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NP10679 2914889-88-4 Angiogenesis GPCR/G Protein Immunology/Inflammation JAK/STAT signaling Metabolism Neuroscience Tyrosine Kinase/Adaptors HER NMDAR P450 Histamine Receptor Inhibitor inhibitor inhibit