Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NPT200-11 is an orally bioavailable and brain penetrating inhibitor of accumulation of alpha-synuclein (ASYN) misfolding and aggregation. NPT200-11 can be used in studies about the underlying pathology of synucleinopathies including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Multiple Systems Atrophy (MSA).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | お問い合わせ | ¥ 45,000 |
5 mg | お問い合わせ | ¥ 100,500 |
10 mg | お問い合わせ | ¥ 150,500 |
25 mg | お問い合わせ | ¥ 270,500 |
50 mg | お問い合わせ | ¥ 406,000 |
100 mg | お問い合わせ | ¥ 609,000 |
200 mg | お問い合わせ | ¥ 913,000 |
説明 | NPT200-11 is an orally bioavailable and brain penetrating inhibitor of accumulation of alpha-synuclein (ASYN) misfolding and aggregation. NPT200-11 can be used in studies about the underlying pathology of synucleinopathies including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Multiple Systems Atrophy (MSA). |
In vivo | In the Line 61 transgenic mouse model overexpressing human wild type ASYN, NPT200-11 (5 mg/kg; i.p.) results in a time-dependent and progressive reduction in retinal ASYN pathology. NPT200-11 reduced alpha-synuclein pathology in cortex, reduced associated neuroinflammation (astrogliosis), normalized striatal levels of the dopamine transporter (DAT) and improved motor function[1]. |
分子量 | N/A |
CAS No. | 2227057-23-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
You can also refer to dose conversion for different animals. 詳細
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NPT200-11 2227057-23-8 Others NPT200 11 NPT20011 Inhibitor inhibitor inhibit