Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson's disease (PD) research, illustrating its potential in therapeutic applications [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson's disease (PD) research, illustrating its potential in therapeutic applications [1]. |
In vitro | Nrf2/HO-1 activator 1 demonstrates significant neuroprotective effects at concentrations ranging from 0.3 to 30 μM over 24 hours in cell death models induced by 6-OHDA and rotenone. Additionally, at concentrations of 1 to 30 μM over 6 hours, it effectively enhances HO-1 expression in PC12 cells. Furthermore, at a fixed concentration of 12 μM across varying durations from 1 to 12 hours, it actively promotes the phosphorylation of ERK1/2, JNK, and Akt in PC12 cells. In cell viability assays using PC12 cells treated for 4 hours, it showcases its capability to inhibit 6-OHDA-induced toxicity with an IC50 of 3.9 μM and rotenone-induced toxicity with an IC50 of 4.8 μM. Western blot analysis corroborates these findings, revealing dose-dependent inductions in HO-1 expression, most notably achieving a 2-fold increase at 30 μM, and the phosphorylation of ERK1/2, JNK, and Akt, further confirming its neuroprotective mechanisms [1]. |
In vivo | Nrf2/HO-1 activator 1 reduces lipid peroxide production by 50.5% at a concentration of 100 μM in rat brain homogenates [1]. |
分子量 | 350.36 |
分子式 | C21H18O5 |
CAS No. | 2883506-60-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Nrf2/HO-1 activator 1 2883506-60-1 Inhibitor inhibitor inhibit