Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the helix destabilization of duplex DNA (dsDNA) oligonucleotides, playing a role in processes such as DNA replication, repair, recombination, and the DNA damage response signaling pathway [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 18,000 |
5 mg | 約 35 days | ¥ 53,500 |
10 mg | 約 35 days | ¥ 63,000 |
25 mg | 約 35 days | ¥ 132,000 |
説明 | NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the helix destabilization of duplex DNA (dsDNA) oligonucleotides, playing a role in processes such as DNA replication, repair, recombination, and the DNA damage response signaling pathway [1]. |
In vitro | NSC15520, at concentrations ranging from 10 to 0.5 x 10^-3.5 M, inhibits the interaction between RPA and the GST-p53 peptide with an IC50 of 10 μM [1]. |
分子量 | 418.52 |
分子式 | C24H34O6 |
CAS No. | 730960-98-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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NSC15520 730960-98-2 Inhibitor inhibitor inhibit