Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 μM by Alpha screen, Kd = 0.80 μM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has no acute toxicity. See the Structural Genomics Consortium (SGC) website for more information.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 25,000 |
50 mg | 約6-8 週間 | ¥ 171,500 |
100 mg | 約6-8 週間 | ¥ 273,500 |
説明 | NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 μM by Alpha screen, Kd = 0.80 μM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has no acute toxicity. See the Structural Genomics Consortium (SGC) website for more information. |
ターゲット&IC50 | BRD7:5.5 μM (IC50), CECR2:47 nM (IC50), CECR2:80 nM (Kd), BRD4:>37 μM (IC50), BRD9:2.3 μM (IC50) |
別名 | NVS-CECR2-1 |
分子量 | 495.68 |
分子式 | C27H37N5O2S |
CAS No. | 1992047-61-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 0.3 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NVS-CECR2-1 1992047-61-6 NVS-CECR-2-1 NVS CECR2 1 NVSCECR21 Inhibitor inhibitor inhibit