Powder: -20°C for 3 years | In solvent: -80°C for 1 year
O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約 35 days | ¥ 35,500 |
10 mg | 約 35 days | ¥ 66,000 |
25 mg | 約 35 days | ¥ 155,000 |
説明 | O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3 |
分子量 | 446.47 |
分子式 | C21H22N2O7S |
CAS No. | 1384441-38-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL
DMSO: 30 mg/mL
DMF: 30 mg/mL
You can also refer to dose conversion for different animals. 詳細
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O-Demethyl Apremilast 1384441-38-6 O Demethyl Apremilast ODemethyl Apremilast Inhibitor inhibitor inhibit