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Ontuxizumab (MORAb-004) is a monoclonal antibody targeting endomelanic acid with anti-tumor effects.Ontuxizumab is a potent IgG1/κ anti-endothelin (TEM-1 or CD248) monoclonal antibody for the treatment of metastatic melanoma.
説明 | Ontuxizumab (MORAb-004) is a monoclonal antibody targeting endomelanic acid with anti-tumor effects.Ontuxizumab is a potent IgG1/κ anti-endothelin (TEM-1 or CD248) monoclonal antibody for the treatment of metastatic melanoma. |
In vitro | Ontuxizumab induces internalization of CD248 in a dose-dependent manner, with a reduction of 46% in surface CD248 on human dermal fibroblasts after 12 hours of treatment with concentrations ranging from 0 to 100 μg/mL[1]. |
In vivo | In human CD248 knock-in mice, Ontuxizumab demonstrates antitumor effects when administered at a dose of 50 mg/kg via intravenous injection, given five times a day for five consecutive days[1]. |
別名 | MORAb-004 |
分子量 | N/A |
CAS No. | 946415-62-9 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Ontuxizumab 946415-62-9 Others MORAb-004 Inhibitor inhibitor inhibit