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Ordesekimab (AMG 714) is a human IgG1 κ-anti-IL-15 (Interleukin Related) monoclonal antibody. Ordesekimab binds competitively to IL-15, inhibiting the interaction of IL-15 with the common gamma chain of the IL-2Rβ and IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab can be used to study non-reactive celiac disease (NRCD).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 22,500 |
5 mg | 在庫あり | ¥ 45,500 |
10 mg | 在庫あり | ¥ 78,000 |
25 mg | 在庫あり | ¥ 131,500 |
50 mg | 在庫あり | ¥ 189,000 |
説明 | Ordesekimab (AMG 714) is a human IgG1 κ-anti-IL-15 (Interleukin Related) monoclonal antibody. Ordesekimab binds competitively to IL-15, inhibiting the interaction of IL-15 with the common gamma chain of the IL-2Rβ and IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab can be used to study non-reactive celiac disease (NRCD). |
In vitro | Theoretically, Ordesekimab (AMG 714) may promote antibody-dependent cell-mediated cytotoxicity (ADCC) by concurrently binding to Fcγ receptor (R) IIIα on natural killer (NK) cells and the IL-15/IL-15Rα complex on cells like monocytes, targeting cells expressing IL-15Rα[1]. |
別名 | AMG 714, PRV-015 |
分子量 | N/A |
CAS No. | 879293-15-9 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Ordesekimab 879293-15-9 Immunology/Inflammation IL Receptor PRV015 AMG 714 AMG-714 PRV-015 PRV 015 AMG714 Inhibitor inhibitor inhibit