Powder: -20°C for 3 years | In solvent: -80°C for 1 year
P163-0892 is a highly effective and specific antifungal compound targeting Cryptococcus species. Additionally, P163-0892 demonstrates moderate capability to penetrate the blood-brain barrier [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 491,500 |
50 mg | 約6-8 週間 | ¥ 639,500 |
100 mg | 約6-8 週間 | ¥ 808,000 |
説明 | P163-0892 is a highly effective and specific antifungal compound targeting Cryptococcus species. Additionally, P163-0892 demonstrates moderate capability to penetrate the blood-brain barrier [1]. |
In vitro | P163-0892, at concentrations ranging from 0-32 μg/mL over 48 hours, demonstrates antifungal efficacy, achieving minimum inhibitory concentrations (MICs) of 0.25 μg/mL and 0.5 μg/mL against Cryptococcus neoformans and Cryptococcus gattii, respectively. Notably, it also exhibits favorable aqueous solubility and is devoid of cytotoxic and significant cardiotoxic effects. |
In vivo | P163-0892 (10 mg/kg; 5 days) significantly extends the survival of larvae infected with either C. neoformans or C. gattii [1]. Animal Model: Wax moth larva infected with C. neoformans H99 or C. gattii WM178 [1] Dosage: 10 mg/kg Administration: 5 days Result: Increased the survival rate of larvae. Animal Model: Male Sprague–Dawley rats weighing 200–250 g [1] Dosage: 2 mg/kg or 5 mg/kg Administration: Intravenous or oral administration (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of P163-0892 a route dose (mg/kg) C 0 (ng/mL) C max (ng/mL) T 1/2 (h) T max (h) AUC 0-inf (h ng/mL) Cl (mL/h/kg) MRT 0-t (h) Vd ss (L/kg) BA (%) iv 2 mg/kg 2460 7.61 749 172 2.63 7.12 po 5 mg/kg 2.97 15.3 3.17 NR |
分子量 | 356.44 |
分子式 | C19H20N2O3S |
CAS No. | 1574576-45-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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P163-0892 1574576-45-6 Others Inhibitor inhibitor inhibit