keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent transcription5. Interestingly, the COOH terminus of 53BP1 contains tandem BRCA1 COOH terminus (BRCT) motifs.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | お問い合わせ | ¥ 11,500 |
5 mg | お問い合わせ | ¥ 33,000 |
10 mg | お問い合わせ | ¥ 54,000 |
25 mg | お問い合わせ | ¥ 75,500 |
説明 | Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent transcription5. Interestingly, the COOH terminus of 53BP1 contains tandem BRCA1 COOH terminus (BRCT) motifs. |
In vitro | 53BP1 becomes hyperphosphorylated and rapidly relocates to the sites of DNA strand breaks in response to ionizing radiation. 53BP1 foci formation is reduced in ATM-deficient cells and can be inhibited by wortmannin in ATM wild-type cells. Moreover, radiation-induced hyperphosphorylation of 53BP1 is absent in cells treated with wortmannin, as well as in ATM-deficient cells. 53BP1 participates in DNA damage–signaling pathways and is regulated by ATM after γ-radiation6. |
分子量 | 1242.38 |
分子式 | C57H87N13O18 |
CAS No. | TP2299 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≥124.2mg/mL
You can also refer to dose conversion for different animals. 詳細
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tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] TP2299 Others tumor protein p-53 binding protein fragment [Homo sapiens]/[Mus musculus] Inhibitor inhibitor inhibit