Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while also significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while also significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1]. |
In vitro | PARP1-IN-10 (compound 12c) demonstrated no cytotoxicity at a concentration of 10 μM over 48 hours against NCI-60 human tumor cell lines. It effectively inhibited the MDA-MB-436 cell line, presenting an IC50 value of 3.73 μM. Furthermore, administration of PARP1-IN-10 at concentrations of 1 and 3.73 μM for 48 hours induced cell cycle arrest at the G2/M phase in a dose-dependent manner. Additionally, at a lower dose of 0.5 μM for 48 hours, PARP1-IN-10 significantly enhanced the anti-proliferative effect of temozolomide (TMZ) in A549 cell lines, making it approximately 7 times more effective than TMZ alone (reducing the IC50 from 24.2 μM to 3.64 μM). These results, encompassing cytotoxicity assays, cell cycle, and apoptosis analysis, underline the potential of PARP1-IN-10 as a therapeutic agent, specific in its action and synergistic with existing treatments like TMZ. |
分子量 | 385.41 |
分子式 | C20H23N3O5 |
CAS No. | 2494001-21-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PARP1-IN-10 2494001-21-5 Inhibitor inhibitor inhibit