Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM). Pexidartinib hydrochloride is 10-100 times more selective for c-Kit and CSF1R than for other related kinases, acting on FLT3 (IC50: 160 nM), KDR (VEGFR2) (IC50: 350 nM), LCK (IC50: 860 nM), FLT1 (VEGFR1) (Pexidartinib hydrochloride induces apoptosis and exhibits anti-tumour effects.
説明 | Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM). Pexidartinib hydrochloride is 10-100 times more selective for c-Kit and CSF1R than for other related kinases, acting on FLT3 (IC50: 160 nM), KDR (VEGFR2) (IC50: 350 nM), LCK (IC50: 860 nM), FLT1 (VEGFR1) (Pexidartinib hydrochloride induces apoptosis and exhibits anti-tumour effects. |
分子量 | 454.28 |
分子式 | C20H16Cl2F3N5 |
CAS No. | 2040295-03-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Pexidartinib hydrochloride 2040295-03-0 Inhibitor inhibitor inhibit