Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ph-Ph+ is a hemiprotonic compound derived from the dimerization of phenanthroline (ph). It exhibits remarkable antitumor, antibacterial, and antifungal properties [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | Ph-Ph+ is a hemiprotonic compound derived from the dimerization of phenanthroline (ph). It exhibits remarkable antitumor, antibacterial, and antifungal properties [1]. |
In vitro | Ph-Ph+ (0.0039-2 μmol/mL; 24-72 hours) selectively inhibits tumor cell proliferation in a dose- and time-dependent manner across several cell lines, including H22, U251MG, SH-SY5Y, B16, and A549, without impacting the viability of human L02 and HUVEC cells. Optical microscopy reveals that Ph-Ph+ treatment causes tumor cells to shrink and form apoptotic bodies, indicating a mechanism of selective antitumor activity through apoptosis induction. Additionally, Ph-Ph+ exhibits broad-spectrum antibacterial and antifungal effects, effectively combatting drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus. |
In vivo | Tumor-bearing mice, created through subcutaneous transplantation of the mouse hepatoma H22 cell line, exhibited reduced tumor volume and weight following treatment with Ph-Ph+ (2-8 mg/kg; i.v; over 8 days) in a dose-dependent manner [1]. Additionally, in liver cancer animal models with concomitant fungal infection, Ph-Ph+ administration (2-8 mg/kg; i.v; daily for 9 days) not only inhibited the proliferation of hepatoma cells but also alleviated pneumonia and encephalitis induced by Cryptococcus neoformans [1]. |
分子量 | 361.42 |
分子式 | C24H17N4+ |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ph-Ph+ Inhibitor inhibitor inhibit