Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHA 568487 a selective agonist of alpha-7 nicotinic acetylcholine receptor ( α-7 nAchR ). PHA-568487 shows rapid brain penetration. PHA 568487 reduces oxidative stress and neuroinflammation.
説明 | PHA 568487 a selective agonist of alpha-7 nicotinic acetylcholine receptor ( α-7 nAchR ). PHA-568487 shows rapid brain penetration. PHA 568487 reduces oxidative stress and neuroinflammation. |
In vitro | PHA 568487 enhances anti-oxidant gene expression while reducing oxidative stress and NF-κB p65 phosphorylation. Conversely, Methyllycaconitine (MLA) exhibits opposite effects [2]. Additionally, PHA upregulates anti-oxidant genes and NADPH oxidase expression, correlating with diminished NF-kB p65 phosphorylation within microglia/macrophages [3]. |
In vivo | PHA 568487 effectively mitigates neuronal damage and functional impairments in mice and rats suffering from ischemic stroke, with and without concurrent tibia fracture. In C57BL/6J male mice models, PHA 568487 and Methyllycaconitine (MLA) administered intraperitoneally on the first two days post-middle cerebral artery occlusion (pMCAO) demonstrated the most pronounced reduction in cerebral infarction and improvement in behavioral outcomes. Similarly, in adult male Sprague-Dawley rats, a daily intraperitoneal injection of PHA 568487 significantly decreased infarct volumes and enhanced neurological results, marking a notable improvement in recovery from ischemic conditions. |
分子量 | 404.419 |
分子式 | C20H24N2O7 |
CAS No. | 527680-57-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PHA 568487 527680-57-5 Inhibitor inhibitor inhibit