Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is particularly valuable for anticancer research purposes [1]. (AC 50: the concentration at which 50% enzyme activation occurs.)
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is particularly valuable for anticancer research purposes [1]. (AC 50: the concentration at which 50% enzyme activation occurs.) |
In vivo | PKM2 activator 3, also known as compound 66, exhibits favorable pharmacokinetic properties, including efficient Caco-2 permeability and a low efflux ratio of 0.84. It demonstrates robust microsomal stability, with a half-life of 277.2 minutes in human liver microsomes and 117.5 minutes in mouse liver microsomes [1]. |
分子量 | 372.77 |
分子式 | C15H11ClF2N2O3S |
CAS No. | 1346113-84-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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PKM2 activator 3 1346113-84-5 Inhibitor inhibitor inhibit